Table 2 HPV status in cervical cancer predicted independently better PFS in univariate and multivariate analyses.

From: Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers

 

Univariate analyses

Multivariate analyses

Clinicopathologic characteristics

HR

95% CI

P value

HR

95% CI

P value

Age (>48 years)

1.19

0.900–1.574

0.223

   

Postmenopausal

1.243

0.937–1.650

1.243

   

Tumor sizes (>4 cm)

1.432

1.072–1.912

0.015

1.09

0.81–1.47

0.563

Depth of myometrial invasion (>1/2)

3.632

2.309–5.713

<0.001

2.12

1.40–3.46

0.003

Parametrial involvement

3.31

2.217–4.914

<0.001

1.47

0.96–2.27

0.078

LVSI

2.356

1.780–3.117

<0.001

1.62

1.18–2.21

0.003

Node status

3.405

2.572–4.508

<0.001

2.09

1.51–2.89

<0.001

Histological subtypesa

1.825

1.364–2.441

<0.001

2.13

1.02–1.86

<0.001

FIGO status

1.82

1.360–2.435

<0.001

1.38

1.02–1.86

0.039

HPV statusb

0.407

0.222–0.748

0.004

0.53

0.28–0.99

0.045

  1. SCC squamous cell carcinoma, LVSI lymphovascular invasion.
  2. aNon-SCC vs. SCC.
  3. bHPV positive vs. HPV negative.
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