Fig. 3: High heterogeneity patients have a better prognosis.

a Simpson’s diversity index for K = 9. Higher Simpson’s diversity index value indicates higher heterogeneity level of the patient. The line within the box displays the median value. b Survival difference between patients with high metabolic heterogeneity levels and patients with low metabolic heterogeneity levels. c Numbers of high heterogeneity and low heterogeneity patients in trastuzumab-sensitive and trastuzumab-resistant patients. p value was calculated using the Fisher exact test. d Representative higher-magnification ion distribution images of three high- and low-heterogeneity patients within the measured tumour areas. **p < 0.01.