Fig. 4: Tumour metabolic subpopulations are associated with patient survival outcomes and trastuzumab therapy response.

Survival analysis of a nine tumour metabolic subpopulations in Kaplan–Meier curves. In pairwise comparison, there are significant differences in survival between b subpopulations 1 and 4, c subpopulations 1 and 5, d subpopulations 4 and 9, and e subpopulations 5 and 9 by Wald test. f Association of nine tumour metabolic subpopulations with trastuzumab therapy response. The subpopulations which positively correlated with trastuzumab response were defined as trastuzumab-sensitive subpopulations; The subpopulation which negatively correlated with trastuzumab response was defined as trastuzumab-resistant subpopulation. *\(p\) < 0.05, **\(p\) < 0.01.