Fig. 3: Immunogenic features of MIBC patients stratified by CDK6 expression. | British Journal of Cancer

Fig. 3: Immunogenic features of MIBC patients stratified by CDK6 expression.

From: Integrative score based on CDK6, PD-L1 and TMB predicts response to platinum-based chemotherapy and PD-1/PD-L1 blockade in muscle-invasive bladder cancer

Fig. 3

a Box plots for the signature of MHC-I, MHC-II and antigen presentation machinery (APM) in TCGA cohort. b Violin plots illustrating the differences in T cell receptor (TCR) diversity (TCR Shannon) and richness within response score subgroups in TCGA cohort. c Box plot for immune score in TCGA cohort. d Stacked bar chart illustrating the distribution of the immune phenotypes in response score subgroups in IMvigor210 cohort. Heatmap for the correlation between response score and immune indicators in TCGA cohort (e) and IMvigor210 cohort (f). The mean rank of Kruskal-Wallis test was standardised by z-score in Fig. 3f. Kruskal-Wallis test and Chi-square test were applied. All reported p values were two sided. *P < 0.05, **p < 0.01 and ***p < 0.001. MHC major histocompatibility complex, TCR T cell receptor, TEM effector memory T cells, Trm tissue resident memory T cells.

Back to article page