Fig. 5: HPV perturbs DNA damage response signalling pathway.
From: Navigating therapeutic strategies: HPV classification in head and neck cancer
HPV infection could manipulate the normal DNA repair systems in the cells and thus enhance the level of chromosomal instability and DNA breakage. This phenomenon ultimately increases the rate of HPV integration into the host genome. HPV human papillomavirus, RAD DNA repair protein, MRE11 meiotic recombination 11 homologue A, NBS1 Nijmegen breakage syndrome 1, ATM ataxia telangiectasia mutated, Chk checkpoint kinase, 53BP1 p53-binding protein 1, MDC1 mediator of DNA damage checkpoint protein 1, RPA replication protein A, HUS haemolytic-uraemic syndrome, ATRIP ATR-interacting protein, ATR ataxia telangiectasia and Rad3-related protein, TOPBP1 DNA topoisomerase 2-binding protein 1.
