Fig. 3: Defining molecular features of 3 subtypes in MYCN non-amplified neuroblastomas. | British Journal of Cancer

Fig. 3: Defining molecular features of 3 subtypes in MYCN non-amplified neuroblastomas.

From: Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification

Fig. 3

a Heatmap showing differential expression of selected genes. Red indicates up-regulation and blue for down-regulation. Colour bars show subgroup information. b Gene set enrichment analysis (GSEA) in 3 subtypes. *FDR (false discovery rate) <0.25; **FDR < 0.05; ***FDR < 0.01. c Weighted gene co-expression network analysis (WGCNA) showing 3 molecular modules. Nodes are colour-coded according to the WGCNA modules. Representative enriched pathway terms are indicated. d Overlay of the median-cantered log2 fold change values per subgroup on the network.

Back to article page