Fig. 4: Subgroup 2 shows a “MYCN” signature, potentially induced by Aurora Kinase A overexpression. | British Journal of Cancer

Fig. 4: Subgroup 2 shows a “MYCN” signature, potentially induced by Aurora Kinase A overexpression.

From: Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification

Fig. 4

Violin plots showing MYCN mRNA levels (a) or MYCN scores (b) in neuroblastomas. P values are indicated. c Multivariate analysis of MYCN score and risk status in MYCN non-amplified neuroblastomas. HR (hazard ratio), 95% CI (confidence interval), patient number (n), and P values are shown. d Protein-protein interaction (PPI) network showing an interaction between AURKA and MYCN. e Violin plot showing AURKA mRNA levels in neuroblastomas. P values are indicated. f Kaplan−Meier plot showing the overall survival in samples with low vs. high AURKA expression. The numbers below are n (%). HR (hazard ratio), 95% CI (confidence interval), patient number (n), and P values are shown.

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