Fig. 4: Spectrum in peak times of selected human circulating immunological factors with a proven 24-h rhythm relevant to cancer immunotherapy.
From: Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
a Healthy (male) subjects. CD8 cytotoxic Central memory [red], effector [blue], plasma cortisol [green]. b Salivary cortisol in four individual patients with advanced cancer. c Distribution of daily timings of ICI administration in two studies: Karaboué et al. Cancers [11] [green] and Qian et al. Lancet Oncol. [12] [purple].
