Fig. 6: Schematic representation of the mechanism for the preferential production of IL-8 by CAFs in gastric cancer.
From: Tumour cell-derived serglycin promotes IL-8 secretion of CAFs in gastric cancer
Tumour cell-derived SRGN upregulates KDM5B expression in CAFs via interacting with its receptor CD44 and increases IL-8 production in CAFs. IL-8 further recruits neutrophils into the TME. The infiltrated neutrophils, namely, tumour-associated neutrophils (TANs), upregulate SRGN expression in gastric cancer cells via REG4. Thus, the SRGN-IL-8-TANs-SRGN loop facilitates tumour progression.
