Fig. 1: Functional analysis and filtering identifies candidate genes altered in NS LUAD.

a Workflow used to predict variants in genes undergoing positive selection in LUAD. b A summary table illustrating the presence of genetic mutations in the 21 genes passing functional and prevalence filtering across the 15 tumors. The top bar illustrates total somatic mutations across the cohort with retained functional mutations shown in green. c GO enrichments present in 3 or more samples that have members in novel candidate genes. Black boxes illustrate the gene being annotated with GO.