Fig. 2: Genomic alterations and prevalence of candidate driver genes across expanded panel of LUAD tumors and assessment of two-hit frequency. | British Journal of Cancer

Fig. 2: Genomic alterations and prevalence of candidate driver genes across expanded panel of LUAD tumors and assessment of two-hit frequency.

From: Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response

Fig. 2: Genomic alterations and prevalence of candidate driver genes across expanded panel of LUAD tumors and assessment of two-hit frequency.

a Oncoprint represents integration of genetic mutation and copy number status of the 12 identified candidates (bottom) and 10 known drivers (top) across 83 LUAD tumors. Samples with no alterations in the 21 genes are not shown. Frequency of disruption across the dataset is shown in the right panel and patient demographics are illustrated on the bottom. b Frequency of two-allele disruption in candidates in BCCA and TCGA cohorts, including homozygous mutations, deep deletions, and patients with a heterozygous mutation and loss. TP53 is shown as a control.

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