Table 2 Results of linear regression model for diagnostic interval in days.

From: The effect of comorbidities on diagnostic interval for lung cancer in England: a cohort study using electronic health record data

 

Model 1 (n = 11870)

 

Model 2 (n = 9837)

 

Predictor

Adjusted B (95% CI) (days)

p

Adjusted B (95% CI) (days)

p

Sex (female)

7.24 (3.25, 11.24)

<0.001

4.95 (0.45, 9.45)

0.031

Age at diagnosis (y)

0.355 (0.090, 0.620)

0.009

0.313 (0.015, 0.611)

0.040

Diagnosis year

 <2000

0.00

0.00

 2000–2004

−12.82 (−21.35, −4.28)

0.003

−12.18 (−22.77, −1.59)

0.024

 2005–2009

−10.70 (−19.00, −2.41)

0.011

−11.40 (−21.68, −1.13)

0.030

 2010–2014

−7.91 (−16.40, 0.58)

0.068

−9.78 (−20.21, 0.65)

0.066

 2015–2019

−17.30 (−26.86, −7.75)

<0.001

−19.36 (−30.75, −7.98)

<0.001

AE conditions

 None (reference)

0.00

0.00

 One

30.55 (26.09, 35.00)

<0.001

27.94 (23.03, 32,85)

<0.001

 Two or more

73.83 (67.80, 79.87)

<0.001

70.97 (64.45, 77.48)

<0.001

Background consultation frequency (visits/y)

2.03 (1.85, 2.22)

<0.001

1.98 (1.78, 2.18)

<0.001

Increase in frequency

 No increase (reference)

0.00

0.00

 Increase

22.72 (17.78, 27.65)

<0.001

22.52 (17.11, 27.93)

<0.001

IMD

1.74 (0.30, 3.19)

0.018

1.60 (0.00, 3.20)

0.050

First symptom

 Cough (reference)

0.00

0.00

 Dyspnoea

−7.67 (−13.46, −1.88)

0.009

−4.88 (−11.21, 1.46)

0.131

 Chest infection

9.11 (3.18, 15.04)

0.003

11.05 (4.43, 17.67)

0.001

 Chest pain

−17.79 (−25.51, −10.06)

<0.001

−19.55 (−28.00, −11.11)

<0.001

 Fatigue

−9.10 (−17.92, −0.28)

0.043

−6.50 (−16.22, 3.23)

0.191

 Thrombocytosis

−28.65 (−38.05, −19.25)

<0.001

−26.85 (−37.34, −16.35)

<0.001

 Multiple

−17.79 (−27.73, −7.85)

<0.001

−17.30 (−28.06, −6.54)

0.002

 Haemoptysis

−82.61 (−93.41, −71.81)

<0.001

−84.23 (−96.48, −71.98)

<0.001

 Weight loss

−50.52 (−61.87, −39.17)

<0.001

−52.04 (−64.72, −39.37)

<0.001

 Other

−60.97 (−78.99, −42.95)

<0.001

−66.03 (−86.21, −45.85)

<0.001

BMI Category

 Healthy weight (reference)

  

0.00

 Underweight

  

23.35 (12.74, 33.95)

<0.001

 Overweight

  

−5.89 (−10.85, −0.93)

0.020

 Obese

  

−3.60 (−9.75, 2.55)

0.251

Smoking status

 Ever smoker (reference)

  

0.00

 non-smoker

  

−11.43 (−18.63, −4.23)

0.002

 Missing

    

Drinking status

 Current drinker (reference)

  

0.00

 Former drinker

  

6.68 (0.08, 13.28)

0.047

 Non drinker

  

8.24 (1.10, 15.38)

0.024