Fig. 1: Observed and predicted 10-year EOC risks under individual or different combinations of risk factors*.
From: Validation of the BOADICEA model for epithelial tubo-ovarian cancer risk prediction in UK Biobank
*Women were grouped into deciles based on their predicted risks. Each dot represents the mean observed and predicted risk in the decile and the error bar represents the 95% confidence intervals. The dashed line is the reference line with slope equals to 1, on which the observed risk equals to the predicted risk. When the confidence interval intersects with the reference line, the predicted risk in that decile is not significantly different from the observed risk. If the confidence interval of a decile deviates from the reference line, there is a suggestion of either overprediction (below the line) or underprediction (above the line) of EOC risks by the BOADICEA model. Null age-only model, PRS polygenic risk scores, PV pathogenic variants, QRF questionnaire-based risk factors, FH family history.
