Table 1 Summary of characteristics of 199,429 eligible participants at baseline.
From: Validation of the BOADICEA model for epithelial tubo-ovarian cancer risk prediction in UK Biobank
Probands | Unaffected women | Incident EOC patients | |
|---|---|---|---|
199,429 | 198,656 | 773 | |
Variables | Category | N (%) | N (%) |
PVs in six major genes | BRCA1 | 83 (0.04) | 7 (0.91) |
BRCA2 | 405 (0.20) | 24 (3.10) | |
PALB2 | 277 (0.14) | 3 (0.39) | |
RAD51C | 52 (0.03) | 3 (0.39) | |
RAD51D | 63 (0.03) | 2 (0.26) | |
BRIP1 | 309 (0.16) | 5 (0.65) | |
Missing | 13,515 (6.80) | 50 (6.47) | |
Parity | Nulliparous | 37,498 (18.88) | 176 (22.77) |
1 birth | 26,373 (13.28) | 101 (13.07) | |
2 births | 88,274 (44.44) | 332 (42.95) | |
>2 births | 46,386 (23.35) | 164 (21.22) | |
Missing | 125 (0.06) | 0 (0) | |
Menopausal hormone therapy use | Current C-type | 32,588 (16.40) | 146 (18.89) |
Current E-type | 117 (0.06) | 4 (0.52) | |
Former | 36,270 (18.26) | 181 (23.42) | |
Never | 129,163 (65.02) | 440 (56.92) | |
Missing | 518 (0.26) | 2 (0.26) | |
Menopause | Yes | 123,516 (62.18) | 559 (72.32) |
Missing | 1 (0) | 0 (0) | |
Age at start of risk prediction | (40, 45) | 16,015 (8.07) | 25 (3.23) |
(45, 50) | 27,097 (13.65) | 73 (9.44) | |
(50, 55) | 31,643 (15.94) | 99 (12.81) | |
(55, 60) | 35,807 (18.03) | 126 (16.30) | |
(60, 65) | 46,992 (23.67) | 207 (26.78) | |
(65, 70) | 35,644 (17.95) | 216 (27.94) | |
≥70 | 5458 (2.75) | 27 (3.49) | |
Missing | 0 (0) | 0 (0) | |
Mean | 57 | 59 | |
SD | 7.97 | 7.37 | |
Follow-up (years) | Mean | 10 | 6 |
SD | 2 | 3 | |
Standardised PRS | Mean | 0.84 | 1.13 |
SD | 1.02 | 1.04 | |
Missing | 0 (0) | 0 (0) | |
Duration of oral contraceptive use | Never or <1 | 6528 (3.29) | 28 (3.62) |
1–4 | 30,215 (15.22) | 125 (16.17) | |
5–9 | 36,359 (18.31) | 130 (16.82) | |
10-14 | 31,659 (15.94) | 100 (12.94) | |
≥15 | 41,929 (21.12) | 106 (13.71) | |
Missing | 51,966 (26.16) | 265 (34.28) | |
Mean | 10.87 | 9.34 | |
SD | 8.04 | 7.59 | |
Tubal ligation | Yes | 1033 (0.52) | 4 (0.52) |
Missing | 0 (0) | 0 (0) | |
Endometriosis | Yes | 2007 (1.01) | 9 (1.16) |
Missing | 0 (0) | 0 (0) | |
Height (cm) | Mean | 162.7 | 162.2 |
SD | 6.3 | 6.3 | |
Missing | 391 (0.19) | 1 (0.13) | |
BMI | <18.5 | 1512 (0.76) | 3 (0.48) |
(18.5, 25) | 80,143 (40.34) | 289 (37.25) | |
(25, 30) | 72,107 (36.30) | 288 (38.81) | |
≥30 | 44,311 (22.31) | 190 (24.58) | |
Missing | 583 (0.29) | 3 (0.48) |
