Table 3 Hazard ratios of cancers per standard deviation cumulative excess waist circumference degree and duration at Visit 4, in ARIC.

From: Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index

Outcomes

 

Cumulative degree of waist circumferencea (per SD)

Cumulative duration of waist circumferenceb (per SD)

 

Age-adjusted HR (95% CI)

MV-adjusted* HR (95% CI)

Age-adjusted HR (95% CI)

MV-adjusted* HR (95% CI)

Cancers

Men

All Cancers

1514

1.12 (1.04,1.20)

1.11 (1.03,1.19)

1.05 (0.98,1.14)

1.05 (0.97,1.13)

OR-cancers

306

1.13 (0.97,1.32)

1.12 (0.96,1.30)

1.05 (0.88,1.24)

1.05 (0.88,1.24)

NOR-cancers

1208

1.11 (1.03,1.20)

1.11 (1.02,1.20)

1.06 (0.97,1.15)

1.05 (0.96,1.14)

NOR cancers excluding lung and prostate

426

1.15 (1.01,1.3)

1.17 (1.03,1.32)

1.15 (1.00,1.32)

1.15 (1.00,1.32)

Specific cancer sites

 Colorectal

126

1.19 (0.97,1.47)

1.17 (0.95,1.44)

1.03 (0.80,1.32)

1.03 (0.80,1.32)

 Pancreas

45

0.93 (0.58,1.49)

0.91 (0.56,1.48)

1.22 (0.79,1.89)

1.20 (0.78,1.86)

 Kidney

55

0.98 (0.63,1.53)

0.97 (0.63,1.51)

0.89 (0.57,1.39)

0.90 (0.57,1.41)

 Bladder

53

0.97 (0.64,1.47)

1.00 (0.66,1.52)

1.90 (1.31,2.76)

1.88 (1.30,2.72)

 Lung

211

1.26 (1.06,1.50)

1.31 (1.08,1.58)

1.23 (1.01,1.49)

1.18 (0.98,1.43)

 Prostate

571

1.01 (0.89,1.15)

0.98 (0.86,1.11)

0.92 (0.81,1.05)

0.92 (0.80,1.04)

 Metastatic Prostate

34

0.83 (0.44,1.56)

0.79 (0.42,1.48)

1.09 (0.64,1.85)

1.07 (0.63,1.81)

Women

 All Cancers

1239

1.00 (0.90,1.11)

1.01 (0.91,1.12)

1.06 (0.97,1.15)

1.08 (0.99,1.18)

 OR-cancers

751

1.07 (0.94,1.21)

1.07 (0.95,1.22)

1.13 (1.00,1.27)

1.14 (1.01,1.28)

 NOR-cancers

488

0.89 (0.75,1.05)

0.91 (0.77,1.08)

0.98 (0.86,1.13)

1.02 (0.89,1.17)

 NOR cancers excluding lung

336

0.88 (0.71,1.08)

0.90 (0.73,1.10)

0.97 (0.82,1.14)

0.99 (0.84,1.17)

Specific cancer sites

 Colorectal

132

1.46 (1.12,1.92)

1.45 (1.10,1.9)

1.58 (1.20,2.09)

1.57 (1.19,2.07)

 Pancreas

43

1.10 (0.68,1.79)

1.05 (0.64,1.72)

1.27 (0.79,2.03)

1.21 (0.76,1.93)

 Kidney

41

0.93 (0.54,1.58)

0.93 (0.54,1.60)

1.47 (0.86,2.52)

1.48 (0.87,2.54)

 Lung

152

0.90 (0.66,1.23)

0.94 (0.69,1.28)

1.02 (0.80,1.30)

1.08 (0.85,1.38)

 Endometrial

76

1.16 (0.81,1.65)

1.14 (0.80,1.62)

0.91 (0.61,1.35)

0.93 (0.62,1.38)

 Ovarian

40

0.78 (0.40,1.52)

0.85 (0.44,1.64)

1.17 (0.71,1.93)

1.25 (0.75,2.08)

 Post-menopausal breast

357

0.90 (0.74,1.10)

0.91 (0.75,1.11)

1.08 (0.92,1.28)

1.09 (0.93,1.29)

  1. *Multivariable adjustment for baseline age, baseline WC, race, alcohol, smoking and HRT (in women).
  2. aDegree of excess WC is the cumulative sum of the number of WC units ≥102 cm in men and ≥88 cm in women over the exposure period.
  3. bDuration of excess WC is the cumulative sum of the duration of WC above the threshold over the exposure period.
  4. OR obesity-related, NOR non-obesity related, CI confidence interval, HR hazard ratio, BMI body mass index, MV multivariable, WC waist circumference.
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