Table 4 Results for the multivariate analysis.

From: Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas

  

HR (mean)

HR (95% CI)

p

OS

Age

 

1.06

1.01–1.11

0.010

Sex

    
 

male

1

  
 

female

0.98

0.37–2.62

0.974

UICC stage

    
 

stage I/II

1

  
 

stage III

1.43

0.17–12.06

0.744

 

stage IV

2.91

0.35–24.40

0.325

Resection status

    
 

R0

1

  
 

R1/R2

2.16

0.75–6.26

0.156

 

RX

0.79

0.19–3.19

0.738

Combined classification (TB and LVI)

    
 

TB low and L0

1

  
  

TB low/L1, TB high/L0

3.30

1.11–9.77

0.031

  

TB high and L1

13.58

3.83–48.11

<0.001

PFS

Age

 

1.02

0.97–1.08

0.409

Sex

    
 

male

1

  
 

female

0.75

0.26–2.19

0.604

UICC stage

    
 

stage I/II

1

  
 

stage III

0.84

0.17–4.20

0.827

 

stage IV

1.21

0.23–6.34

0.823

Resection status

    
 

R0

1

  
 

R1/R2

1.83

0.53–6.30

0.337

 

RX

1.76

0.53–5.90

0.357

Combined classification (TB and LVI)

    
 

TB low and L0

1

  
  

TB low/L1, TB high/L0

4.26

1.31–13.83

0.016

  

TB high and L1

26.34

6.88–100.89

<0.001

  1. HR Hazard ratio, 95% CI 95% confidence interval, OS Overall survival, PFS Progression-free survival, TB Tumor budding (10 HPF), TILs Tumor infiltrating lymphocytes, UICC Union internationale contre le cancer.
  2. Bold values indicate statistical significance.
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