Table 2 Median exposure per group (C_min).

	All patients	Adequate	Low
Total patients	167	56	111
PK samples total	1234	392	842
PK samples per patient	7 [4–11]	7 [3.8-9]	6 [4–11]
Median exposure (ng/mL)	16.5 [11.0–24.1]	20.8 [16.0–30.9]	14 [9.5–20.4]
Median exposure before intervention (ng/mL)	NA	NA	7.95 [5.65–13.0]*
Median exposure after intervention (ng/mL)	NA	NA	20.5 [14.3–34.0]*

Data are expressed as number or as median [interquartile range]. *: only including patients who had an evaluable intervention (n = 86). Adequate: patients with all pharmacokinetic levels ≥8.4 ng/mL. Low: patients with ≥1 pharmacokinetic level <8.4 ng/mL.
C_min minimum plasma concentration at steady-state, PK pharmacokinetic, ng/mL nanogram per millilitre.

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