Fig. 3: Transcriptional activation of proto-oncogenes from distal promoter-enhancer interaction. | British Journal of Cancer

Fig. 3: Transcriptional activation of proto-oncogenes from distal promoter-enhancer interaction.

From: The epigenetic basis of hepatocellular carcinoma – mechanisms and potential directions for biomarkers and therapeutics

Fig. 3

In some cases of HCC, aberrant chromatin loop formation brings de novo distal enhancers in close proximity to the promoter of several proto-oncogenes. The chromatin loop is stabilized by the CCCTC-binding factor (CTCF) and the cohesin complex to facilitate gene transcription. These interactions are associated with increased neovascularization, tumor growth, invasion, and metastasis in HCC.

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