Table 1 Characteristics of the participants from the DD2 cohort of individuals newly diagnosed with type 2 diabetes according to age- and sex corrected YKL-40 percentile categories.
From: YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study
Covariates | Strata | Age and sex corrected YKL-40 percentile categories | |||||
|---|---|---|---|---|---|---|---|
0–33% | 34–66% | 67–90% | 91–95% | 96–100% | Overall | ||
Number of participants | (N = 2975) | (N = 2970) | (N = 2160) | (N = 451) | (N = 454) | 9010 | |
Age, years | 59.96 (11.37) | 60.44 (11.58) | 60.67 (11.54) | 60.81 (11.40) | 60.94 (11.85) | 60.38 (11.51) | |
Sex | |||||||
Female | 1223 (41.1%) | 1222 (41.1%) | 889 (41.2%) | 185 (41.0%) | 187 (41.2%) | 3706 (41.1%) | |
Male | 1752 (58.9%) | 1748 (58.9%) | 1271 (58.8%) | 266 (59.0%) | 267 (58.8%) | 5304 (58.9%) | |
Family history of diabetesa | |||||||
Noa | 1089 (36.6%) | 1087 (36.6%) | 876 (40.6%) | 184 (40.8%) | 199 (43.8%) | 3435 (38.1%) | |
Yes | 1886 (63.4%) | 1883 (63.4%) | 1284 (59.4%) | 267 (59.2%) | 255 (56.2%) | 5575 (61.9%) | |
Diabetes duration, years | 1.78 (2.23) | 1.78 (2.23) | 1.83 (2.51) | 1.80 (2.39) | 1.97 (2.59) | 2.04 (2.57) | |
Body mass index, kg/m² | 30.37 (5.66) | 30.37 (5.66) | 31.45 (5.97) | 32.74 (6.66) | 33.11 (7.93) | 32.54 (7.03) | |
Missing | 1020 (34.3%) | 990 (33.3%) | 691 (32.0%) | 144 (31.9%) | 147 (32.4%) | 2992 (33.2%) | |
Waist-to-hip ratio | 0.97 (0.09) | 0.98 (0.09) | 0.99 (0.08) | 0.99 (0.09) | 1.00 (0.08) | 0.98 (0.09) | |
Missing | 33 (1.1%) | 33 (1.1%) | 29 (1.3%) | 8 (1.8%) | 6 (1.3%) | 109 (1.2%) | |
Alcohol overconsumptiona | |||||||
No | 2858 (96.1%) | 2853 (96.1%) | 1986 (91.9%) | 393 (87.1%) | 353 (77.8%) | 8443 (93.7%) | |
Yes | 117 (3.9%) | 117 (3.9%) | 174 (8.1%) | 58 (12.9%) | 101 (22.2%) | 567 (6.3%) | |
Smoking status | |||||||
Never smoker | 1055 (35.5%) | 1028 (34.6%) | 703 (32.5%) | 132 (29.3%) | 126 (27.8%) | 3044 (33.8%) | |
Ever smoker | 1012 (34.0%) | 997 (33.6%) | 732 (33.9%) | 184 (40.8%) | 175 (38.5%) | 3100 (34.4%) | |
Missing | 908 (30.5%) | 945 (31.8%) | 725 (33.6%) | 135 (29.9%) | 153 (33.7%) | 2866 (31.8%) | |
Physical activitya | |||||||
Low | 2298 (77.2%) | 2386 (80.3%) | 1766 (81.8%) | 372 (82.5%) | 379 (83.5%) | 7201 (79.9%) | |
High | 677 (22.8%) | 584 (19.7%) | 394 (18.2%) | 79 (17.5%) | 75 (16.5%) | 1809 (20.1%) | |
HbA1c, mmol/mol | 50.36 (11.38) | 50.67 (11.32) | 52.42 (12.58) | 53.30 (13.67) | 52.74 (12.62) | 51.24 (11.90) | |
Missing | 507 (17.0%) | 496 (16.7%) | 322 (14.9%) | 55 (12.2%) | 46 (10.1%) | 1426 (15.8%) | |
HOMA2-B, % | 97.52 (43.62) | 99.41 (43.60) | 103.52 (46.04) | 99.83 (46.92) | 99.09 (44.94) | 99.78 (44.49) | |
Missing | 181 (6.1%) | 184 (6.2%) | 127 (5.9%) | 33 (7.3%) | 41 (9.0%) | 566 (6.3%) | |
HOMA2-S, % | 41.92 (21.05) | 38.32 (18.85) | 34.79 (18.54) | 34.93 (21.87) | 32.99 (19.19) | 38.23 (19.93) | |
Missing | 181 (6.1%) | 184 (6.2%) | 127 (5.9%) | 33 (7.3%) | 41 (9.0%) | 566 (6.3%) | |
UACR, mg/g | 26.55 (108.64) | 39.21 (153.43) | 56.18 (210.28) | 59.11 (256.96) | 183.93(1083.88) | 48.11 (300.00) | |
Missing | 1220 (41.0%) | 1143 (38.5%) | 829 (38.4%) | 166 (36.8%) | 158 (34.8%) | 3516 (39.0%) | |
eGFR, mL/min/1.73 m² | 89.28 (16.16) | 87.70 (18.18) | 86.96 (19.63) | 87.19 (20.10) | 85.89 (22.34) | 87.91 (18.31) | |
Missing | 734 (24.7%) | 710 (23.9%) | 466 (21.6%) | 81 (18.0%) | 78 (17.2%) | 2069 (23.0%) | |
LDL cholesterol, mmol/L | 2.32 (0.88) | 2.32 (0.91) | 2.28 (0.92) | 2.28 (0.89) | 2.30 (1.01) | 2.31 (0.90) | |
Missing | 862 (29.0%) | 870 (29.3%) | 608 (28.1%) | 125 (27.7%) | 104 (22.9%) | 2569 (28.5%) | |
Triglycerides, mmol/L | 1.87 (1.66) | 2.01 (1.41) | 2.23 (1.69) | 2.45 (1.61) | 2.34 (1.67) | 2.06 (1.60) | |
Missing | 874 (29.4%) | 886 (29.8%) | 608 (28.1%) | 122 (27.1%) | 104 (22.9%) | 2594 (28.8%) | |
C-reactive protein, mg/L | 2.73 (4.39) | 3.85 (6.76) | 4.83 (7.38) | 6.21 (9.24) | 6.65 (10.60) | 3.97 (6.76) | |
Missing | 51 (1.7%) | 50 (1.7%) | 46 (2.1%) | <10 ( < 2.0%) | <10 ( < 2.0%) | 159 (1.8%) | |
YKL-40, µg/L | 21.51 (6.99) | 41.32 (11.38) | 77.98 (26.99) | 144.89 (41.99) | 328.60 (264.08) | 63.23 (92.17) | |
