Fig. 6: CDBA treatment induces morphological changes suggestive of a transition of EMP-like cells to the epithelial state in pancreatic tumors. | British Journal of Cancer

Fig. 6: CDBA treatment induces morphological changes suggestive of a transition of EMP-like cells to the epithelial state in pancreatic tumors.

From: Benzaldehyde suppresses epithelial-mesenchymal plasticity and overcomes treatment resistance in cancer by targeting the interaction of 14-3-3ζ with H3S28ph

Fig. 6

a Immunohistochemistry of pancreatic tumor tissue from the mouse KPC orthotopic transplantation model. Serial sections of control (Ctrl) and CDBA-treated tumors were stained for E2F2, H3S28ph, LIN28B, and EpCAM. b Serial sections of control and CDBA-treated tumors were similarly stained for E-cadherin, H3S28ph, E2F2, and Ki67 as well as subjected to hematoxylin-eosin (H.E.) staining. c Serial sections of a control tumor were stained for E-cadherin, H3S28ph, and Ki67. d Serial sections of control and CDBA-treated tumors were stained for E-cadherin, H3S28ph, E2F2, ID1, and Ki67 as well as subjected to H.E. staining. Red arrows, cells manifesting mitotic catastrophe with damaged chromatin; orange arrows, canonical expression of E-cadherin at the cell membrane; green arrows, noncanonical E-cadherin expression in the cytoplasm of round EMP-like cells; yellow arrows, high H3S28ph expression associated with chromatin aggregation during mitosis; yellow-green arrows, mitosis-independent H3S28ph expression in round EMP-like cells; pink arrows, pearl formation by cells with epithelial features.

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