British Journal of Cancer

Table 1 Predictors of lymph nodes metastasis on univariable logistic analysis in the training, validation, EUS-FNA and pre-NAT EUS-FNA cohort.

From: Tumor-stroma ratio combined with PD-L1 identifies pancreatic ductal adenocarcinoma patients at risk for lymph node metastases

Variables	Training Cohort						Validation Cohort						EUS-FNA Cohort						pre-NAT EUS-FNA Cohort
	Univariate			Multivariate			Univariate			Multivariate			Univariate			Multivariate			Univariate			Multivariate
	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P
Age(>60 yrs)	0.77	0.35–1.70	0.523				0.66	0.40–1.09	0.106				0.36	0.14–0.93	0.034	0.55	0.19–1.60	0.272	0.71	0.24–2.10	0.537
Sex(Male)	1.18	0.55–2.55	0.675				1.04	0.64–1.70	0.867				1.18	0.48–2.94	0.720				1.87	0.60–5.84	0.280
Differentiation(Poor)	0.89	0.40–2.01	0.782				1.53	0.91–2.57	0.107				NA						NA
PNI(Yes)	0.56	0.24–1.28	0.169				1.26	0.75–2.12	0.380				NA						NA
LVI(Yes)	1.39	0.63–3.04	0.412				1.68	1.00–2.83	0.050	1.58	0.87–2.87	0.130	NA						NA
CA19-9( ≥ 37)	2.10	1.21–3.79	0.041				2.07	1.15–3.72	0.015	1.79	0.91–3.53	0.093	1.79	1.32–5.17	0.031				2.67	1.56–12.62	0.043
Location(Head)	1.76	0.81–3.82	0.152				1.90	1.15–3.14	0.012	1.37	0.77–2.46	0.285	4.90	1.67–14.34	0.004	4.21	1.28–13.84	0.018	1.29	0.43–3.87	0.647
pT Stage(T3-T4)	1.58	0.67–3.72	0.292				0.99	0.57–1.73	0.974				0.95	0.33–2.77	0.931				0.16	0.05–0.53	0.003	0.02	0.00–0.20	0.001
AJCC (III–IV)	17.56	2.22–138.71	0.007				11.31	3.95–32.35	<0.001				Inf	0.00–Inf	0.992				Inf	0.00–Inf	0.993
TSR(Low)	5.85	2.51–13.63	<0.001	6.90	2.79–17.08	<0.001	7.65	4.40–13.28	<0.001	7.38	4.15–13.12	<0.001	4.16	1.57–11.01	0.004	4.24	1.40–12.82	0.010	3.01	1.00–9.07	0.050	20.91	2.03–214.85	0.010
PD-L1(TPS)(Positive)	2.67	1.16–6.17	0.021	3.50	1.35–9.04	0.010	2.23	1.28–3.89	0.005	2.44	1.30–4.59	0.006	2.89	1.03–8.10	0.044	3.07	0.94–10.00	0.062	7.87	2.44–25.45	<0.001	7.56	1.77–32.32	0.006
TSR + PD-L1(TPS)
High/Negative	Reference						Reference						Reference						Reference
High/Positive	3.25	1.00–10.59	0.048				4.07	1.72–9.66	0.001				3.33	0.72–15.54	0.125				10.44	1.66–65.82	0.012
Low/Negative	6.50	2.22–19.01	<0.001				10.96	5.47–21.94	<0.001				4.62	1.35–15.78	0.015				3.36	0.52–21.60	0.202
Low/Postive	26.00	4.89–138.11	<0.001				15.67	6.48–37.85	<0.001				18.00	2.92–110.96	0.002				16.45	2.97–91.23	0.001

PNI perineural invasion, LVI lymphovascular invasion, TSR tumor-stroma ratio, PD-L1 Programmed cell death 1 ligand 1, AJCC The American Joint Committee on Cancer, OR odds ratio, CI confidence interval.
p-values < 0.05 are bolded.

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