Fig. 2: Workflow to be followed for employing ancestry-specific PGS in BOADICEA, in individuals of single ancestry (red-shaded area) and mixed genetic ancestry (yellow-shaded area). | British Journal of Cancer

Fig. 2: Workflow to be followed for employing ancestry-specific PGS in BOADICEA, in individuals of single ancestry (red-shaded area) and mixed genetic ancestry (yellow-shaded area).

From: Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population

Fig. 2: Workflow to be followed for employing ancestry-specific PGS in BOADICEA, in individuals of single ancestry (red-shaded area) and mixed genetic ancestry (yellow-shaded area).The alternative text for this image may have been generated using AI.

Red lines: population-based parameters of the PGS model. Blue lines: ancestry-specific parameters of the PGS from UK Biobank. Green lines: ancestry-specific alphas (αi) from ‘BCAC data’ (BC) or UK Biobank (EOC).

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