Table 2 Summary of ancestry-specific parameters required for standardising the raw PGS in individuals of single ancestry, and for calculating the derived parameters in individuals of mixed genetic ancestry.

From: Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population

Ancestries

Breast cancer

Ovarian cancer

309-SNP PGS

307-SNP PGS

36-SNP PGS

Mean µ

SD σ

Alpha α

Mean µ

SD σ

Alpha α

Mean µ

SD σ

Alpha α

European

-0.335

0.615

0.499

−0.005

0.613

0.497

0.007

0.322

0.223

African

0.292

0.547

0.196

0.634

0.547

0.196

−0.152

0.254

0.178

East Asian

0.268

0.555

0.326

0.611

0.555

0.326

−0.161

0.235

0.171

South Asian

−0.160

0.602

0.331

0.179

0.601

0.329

−0.180

0.278

0.194

  1. For unspecified/unknown ancestry, or other ancestries outside the listed ones, we employed the European PGS parameters.
  2. SD standard deviation.
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