Table 1 Characteristics of participants randomised to the IER + RE and RE groups.

From: Randomised phase-2 screening trial of intermittent energy restriction plus resistance exercise versus resistance exercise alone during chemotherapy for advanced breast cancer

 

IER + RE (n = 35)

RE (n = 33)

All n = 68

Age

57.5 (10.6)a

58.5 (9.2)

58 (9.9)

Weight (Kg)

78.0 (73.0–84.8)b

75.0 (70–88.8)

77.0 (71.0–85.8)

BMI- kg/m2

29.2 (26.4–31.3)b

30.0 (27.0–32.1)

29.8 (27.0–31.6)

Current Chemotherapy typec

 Taxane

11 (31)

11 (33)

22 (32)

 Capecitabine

18 (51)

19 (58)

37 (54)

 Other

6 (17)

3 (9)

9 (13)

Previous breast cancer treatment n(%)

 Adjuvant or neoadjuvant chemotherapy

20 (57)

18 (55)

38 (56)

 Metastatic endocrine

21 (60)

25 (76)

46 (68)

Family history BCc

14 (45)

13 (50)

27 (47)

 Unknown

4

7

11

ER Positivec

29 (83)

29 (88)

58 (85)

HER Positivec

5 (14)

4 (12)

9 (13)

De novo metastatic

8 (23)

13 (39)

21 (31)

Site of metastasesc

 Bone

15 (43)

19 (58)

34 (50)

 Liver

21 (60)

21 (64)

42 (62)

 Lung*

10 (29)

11 (33)

21 (31)

 Brain or leptomeningeal

2 (6)

2 (6)

4 (6)

 Lymph node

16 (46)

12 (36)

28 (41)

 Colon only

1 (3)

–

1 (1)

 Locally advanced/ distal disease

4/31

2/33

6/68

Line of metastatic chemoc

 1

24 (69)

20 (61)

44 (65)

 2+

11 (31)

13 (39)

24 (35)

Menopause**c

 Pre (“still having regular periods”)

5 (14)

3 (9)

8 (12)

 Post (“not having regular periods”)

30 (86)

30 (91)

60 (88)

Smoking statusc

 1 Current

1 (3)

2 (8)

3 (5)

 2 Never

16 (52)

17 (65)

33 (58)

 3 Ex

14 (45)

7 (27)

21 (37)

 Unknown

4

7

11

Ethnicityc

 White

34 (97)

32 (97)

66 (97)

 Black/Mixed

1 (3)

1 (3)

2 (3)

Deprivation quintilec

 1 (Most deprived)

3 (9)

5 (15)

8 (12)

 2

5 (14)

10 (30)

15 (22)

 3

4 (11)

2 (6)

6 (9)

 4

10 (29)

4 (12)

14 (21)

 5 (Least deprived)

12 (34)

12 (36)

24 (35)

Comorbiditiesc

 Cardiac

3 (9)

2 (6)

5 (7)

 Type 2 Diabetes

1 (3)

1 (3)

2 (3)

 Gastric

2 (6)

2 (6)

4 (6)

 Musculoskeletal

2 (6)

2 (6)

4 (6)

 Neurological

3 (9)

1 (3)

4 (6)

 Respiratory

2 (6)

-

2 (3)

 Thyroid

2 (6)

-

2 (3)

 None

21 (60)

26 (79)

47 (69)

  1. *One participant had ovarian metastases in addition to lung a mean(sd) b median(IQ range) c n(%).
  2. **Participants were considered post-menopausal if they were ≥55 years at entry, otherwise they were considered pre/perimenopausal based on criteria by Phipps et al. [52]
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