Fig. 4: Expression of various markers in TPEX, TEX, CTL CD4+ and CD8+ T-cell subsets. | British Journal of Cancer

Fig. 4: Expression of various markers in TPEX, TEX, CTL CD4+ and CD8+ T-cell subsets.

From: Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment

Fig. 4

a Violin plot with the median intensity of PD-1, Ly108, CD69, CD39, and Granzyme B (GrzmB) in CD8+ TPEX and CD8+ TEX cells for responders (R) and non-responders (NR). Patient ID is indicated in colors. Mann-Whitney U-test with Benjamini-Hochberg correction was used to calculate the statistical difference between non-responders and responders. Bars indicate the median with a 95% confidence interval. b Violin plot with the median intensity of PD-1, Ly108, CD39, CD69, and Granzyme B (GrzmB) in CD8+ naive T-cells, CD8+ TPEX and CD8+ TEX cells. Patient ID is indicated in colors. Mann-Whitney U-test with Benjamini-Hochberg correction was used to calculate the statistical difference between non-responders and responders. Bars indicate the median with a 95% confidence interval. c Violin plot with the median intensity of PD-1, Ly108, CD39, CD69 and Granzyme B (GrzmB) in CD4+ TPEX and CD4+ TEX cells for responders (R) and non-responders (NR). Patient ID is indicated in colors. Mann-Whitney U-test with Benjamini-Hochberg correction was used to calculate the statistical difference between non-responders and responders. Bars indicate the median with a 95% confidence interval. d Violin plot with the median intensity of CD39, CD69, IFNγ and Granzyme B (GrzmB) in CD4+ CTL and CD8+ CTL-cells for responders (R) and non-responders (NR). Patient ID is indicated in colors. Mann-Whitney U-test was with Benjamini-Hochberg correction was used to calculate the statistical difference between non-responders and responders. Bars indicate the median with a 95% confidence interval.

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