Fig. 4: Genetic landscape of alterations detected in the cohort (n = 60). | British Journal of Cancer

Fig. 4: Genetic landscape of alterations detected in the cohort (n = 60).

From: Benchmarking standard-of-care and emerging genomic approaches to enhance diagnosis in pediatric acute lymphoblastic leukemia

Fig. 4

a Classification of variant types, showing a predominance of missense mutations. b Top 10 most frequently mutated genes. c Distribution of variant allele frequencies (VAF) for recurrently mutated genes. d Oncoprint depicting individual mutations across samples, with immunophenotypic and molecular classifications annotated at the bottom. Tumour mutational burden (TMB) is shown at the top, and the frequency of gene alterations across samples is summarised on the right. Colour codes indicate mutation types and sample characteristics. Red asterisk indicates IGHM deletion with a common B-cell phenotype. Entities were assigned if a defining driver was found by any techniques as per the WHO/ICC 2022 diagnostic classification criteria.

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