Fig. 2: SeSAMe analysis of DMRs associated with normal and cancer-specific methylation changes. | British Journal of Cancer

Fig. 2: SeSAMe analysis of DMRs associated with normal and cancer-specific methylation changes.

From: Deconvolution of haematological cancer methylation patterns reveals a predominantly non-disease related proliferation signal and uncovers true disease associated methylation changes

Fig. 2

SeSAMe analysis was carried out to compare the characteristics of DMR regions associated with normal and cancer-specific processes. For all four domains up to 20 associations are shown for each group (with fewer shown if there were less than 20 associations with significant ( < 0.05) FDR values). Darker shading indicates an increasing strength of association and white/no shading that no significant association was identified. Associations are shown for (a) sequence context, b histone modifications, c chromatin states, d Transcription factor binding sites. While the chromatin states (c) exhibit a mixed pattern, for the other three domains there is a pronounced overlap between the cancer-specific associations in the B-cell malignancies and the normal methylation changes associated with hypermethylated regions.

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