Table 2 Characteristics of DMR groups.

From: Deconvolution of haematological cancer methylation patterns reveals a predominantly non-disease related proliferation signal and uncovers true disease associated methylation changes

DMR group

CpG sitesa

DMR size

Average CpG sites

Range

Average (bp)

Range (bp)

Proliferation

7.29

(2–110)

1307

4–24170

Differentiation

3.51

(2–29)

597

5–4534

Cancer specific

4.35

(2–18)

756

9–3060

Cancer absent

4.44

(2–13)

630

17–2018

 

Hypermethylation vs hypomethylation

 

Total DMRs hypermethylated

Total DMRs Hypomethylated

fraction hypermethylated (%)

Proliferation

2673

2330

53.4

Differentiation

26

488

5.1

Cancer specific

31

125

19.9

Cancer absent

16

2

88.9

 

Distance to TSSb

 

<1000 bp

>1000 bp

Fraction < 1000 bp (%)

Proliferation

1723

3280

34.4

Differentiation

112

402

21.8

Cancer specific

29

127

18.6

Cancer absent

5

13

27.8

  1. aAverage and range of CpG sites included in DMRs. This represents the number of CpG sites on the methylation array that are in the DMR and not the total number of CpG sites in the genomic region (as the methylation status of intervening CpG sites not represented on the array is unknown, they are not included in the above figures).
  2. bDMRs are stratified by distance from TSS, either <1000 bp or >1000 bp. DMRs that lie near (<1000 bp) a TSS would likely influence gene expression when heavily methylated. DMRs more distal to TSS ( > 1000 bp) would have a less clear impact on expression of the nearest gene.
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