Fig. 1: SCLC cell lines display differential invasive potential in vitro.
From: Fibroblast growth factor signals drive the metastatic behavior in small cell lung cancer
a SCLC cell lines are distinguished based on spheroid formation and invasive sprouting into non-spheroid (top, grey), non-sprouter (middle, ochre) or sprouter (bottom, blue) in a time-dependent manner. Scale bar: 500 µm. b Pie chart displaying grouping of SCLC cell lines. c Quantification of the mean sprout length. At least 10 sprouts of minimum 15 individual spheroids were quantified. ANOVA and Kruskal-Wallis test. ***p < 0.001 d Pooled results comparing the mean area of sprouter (blue; HLHE, H372, H1341, H196) versus non-sprouter (ochre, H524, GLC4, DMS53, H378) groups. ANOVA and Kruskal-Wallis test. ***p < 0.001.
