Fig. 4: Proteomic analysis reveals dysregulated pathways involved in key signalling cascades.
From: Fibroblast growth factor signals drive the metastatic behavior in small cell lung cancer
a 1D annotation enrichment between sprouter (blue; HLHE, H196, H372, H1341) and non-sprouter (ochre; DMS53, GLC4, H378, H524) cell lines based on the KEGG database. b Enrichment of ‘apical junction’ and ‘epithelial-to-mesenchymal transition’ (EMT) in sprouter compared to non-sprouter cell lines based on gene set enrichment analysis (GSEA v4.3.2) performed using proteomics data from sprouter and non-sprouter cell lines, considering the Hallmark dataset. NES (normalised enrichment score) and FDR (False Discovery Rate) q values are shown in the graphs. A FDR q < 0.25 is considered significant. The respective p values are 0.025 for ‘apical junction’ and 0.078 for ‘EMT’. c RNA expression analysis of key mesenchymal markers, including VIM, TWIST1, SNAI1 and MMP1 in pooled non-sprouter (ochre) and non-sprouter (blue) cell lines (n = 4). Data is shown as mean ± SEM. Mann-Whitney test. *p < 0.05, **p < 0.01.
