Table 2 Cox proportional hazards regression models for colorectal cancer-specific survival and overall survival according to UPK2 expression in Cohorts 1 and 2.

From: Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features

  

Cancer-specific survival

Overall survival

Variable

No. of cases

No. of events

Univariable

HR (95% CI)

Multivariable

HR (95% CI)

No. of events

Univariable

HR (95% CI)

Multivariable

HR (95% CI)

Cohort 1

 UPK2

  Negative (0%)

662

126

1 (referent)

1 (referent)

246

1 (referent)

1 (referent)

  Low (1–4%)

68

18

1.42 (0.87–2.32)

0.63 (0.37–1.06)

21

0.84 (0.54–1.32)

0.55 (0.35–0.89)

  High ( ≥ 5%)

26

9

1.97 (1.00–3.88)

1.28 (0.64–2.56)

10

1.14 (0.61–2.15)

0.85 (0.45–1.63)

  ptrend

  

0.021

0.60

 

0.89

0.069

Cohort 2

 UPK2

  Negative (0%)

918

227

1 (referent)

1 (referent)

431

1 (referent)

1 (referent)

  Low (1–4%)

96

44

2.29 (1.66–3.16)

1.63 (1.15–2.31)

66

1.92 (1.45–2.49)

1.54 (1.17–2.03)

  High ( ≥ 5%)

39

22

3.33 (2.15–5.16)

2.31 (1.46–3.65)

30

2.47 (1.71–3.58)

1.83 (1.25–2.68)

  ptrend

  

<0.0001

<0.0001

 

<0.0001

<0.0001

  1. ptrend values were calculated by using the three UPK2 categories as continuous variables in univariable and multivariable Cox proportional hazard regression models.
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