Fig. 2: Patterns of pathogenicity, clonality, and co-occurrence of HRD-associated alterations in cfDNA. | British Journal of Cancer

Fig. 2: Patterns of pathogenicity, clonality, and co-occurrence of HRD-associated alterations in cfDNA.

From: Functional footprints of homologous recombination deficiency in prostate cancer revealed by ctDNA fragmentation and transcription factor accessibility

Fig. 2: Patterns of pathogenicity, clonality, and co-occurrence of HRD-associated alterations in cfDNA.

a Variant allele frequencies (VAFs) of mutations detected in HRR genes and key tumour suppressors (TP53, RB1, PTEN). b Distribution of variant classifications across genes. c Shown are tumour fractions (TF, blue bars) and VAF of detected mutations for clonality assessment of mutations. d Distribution of mutational origin. e Co-occurrence matrix of identified mutations; positive co-occurrence (blue): significantly co-occur; negative co-occurrence (red).

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