Fig. 5: Mutational signatures reveal distinct genomic footprints of HRD, MMR deficiency, and CDK12 inactivation. | British Journal of Cancer

Fig. 5: Mutational signatures reveal distinct genomic footprints of HRD, MMR deficiency, and CDK12 inactivation.

From: Functional footprints of homologous recombination deficiency in prostate cancer revealed by ctDNA fragmentation and transcription factor accessibility

Fig. 5

a Single base substitution (SBS) signatures across mutation-defined and sHRD-stratified groups. b Indel (ID) signature composition per sample. c Copy number (CN) signature contributions reveal enrichment of CN25. t-SNE clustering of d SBS and e ID signatures separate HRD, CDK12, and MMRd cases into partially distinct groups.

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