Fig. 4: PAKi treatment sensitises HGSC cells to activated CD8+ T cell killing. | British Journal of Cancer

Fig. 4: PAKi treatment sensitises HGSC cells to activated CD8+ T cell killing.

From: Investigating PAK inhibition in combination with PD-1 blockade to enhance cytotoxic CD8+ T cell-mediated killing and suppress invasion of ovarian cancer cells

Fig. 4: PAKi treatment sensitises HGSC cells to activated CD8+ T cell killing.The alternative text for this image may have been generated using AI.

Plots show MTT viability results of (a) Ovsaho and (b) Kuramochi cells after PAKi concurrent treatment and PAKi pre-treatment followed by co-culture with PBMC isolated CD8+ T cells at 1:4 (T:E). Statistical significance was calculated with one-way ANOVA and post hoc analyses comparing untreated cells with other experimental conditions unless otherwise indicated: ns, not significant, p  >  0.05; *p  <  0.05; **p  <  0.01; ***p  <  0.001. Plots show PD-L1 surface expression on (c) Ovsaho and (d) Kuramochi cells after 48 h co-culture with activated CD8+ T cells, with an increase in surface PD-L1 in stained populations (blue peaks) compared to isotype control populations (red peaks). All figures represent N = 3 biologically independent experiments.

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