Table 4 Association between lymphocyte subset reconstitution and relapse rate.

From: Lymphocyte subset reconstitution and clinical outcomes following haploidentical hematopoietic stem cell transplantation

Lymphocyte subsets

Median (cells/μL)

5-year RR (95% CI)

HR (95% CI)

P

>median

<median

CD4+ T cell at 9 m

222.5

11.7% (4.9–18%)

22.9% (14.1–30.7%)

0.44 (0.21–0.94)

0.029

naive CD4 + T cell at 1 m

21

14.2% (5.2–22.2%)

30.2% (17.2–41.2%)

0.35 (0.16–0.79)

0.011

memory CD4+ T cell at 9 m

195.4

9.6% (3.4–15.5%)

25.3% (16.1–33.5%)

0.34 (0.17–0.74)

0.006

memory CD4+ T cell at 12 m

226.4

11.3% (5.0–17.2%)

23.8% (14–32.4%)

0.48 (0.24–0.96)

0.039

CD8+ T cell at 9 m

1033

11.1% (4.6–17.2%)

23.8% (14.7–32%)

0.48 (0.23–0.99)

0.049

CD8+ T cell at 12 m

1079.9

12.0% (4.6–18.7%)

22.0% (13.9–29.3%)

0.40 (0.20–0.81)

0.013

naïve CD8+ T cell at 4 m

142

11.5% (6.0–16.7%)

28.2% (19.3–36.2%)

0.43 (0.23–0.79)

0.007

CD3+ CD69+ T cell at 9 m

21.4

7.7% (2.4–12.8%)

26.3% (16.9–34.6%)

0.31 (0.15–0.64)

0.004

CD3+ CD69+ T cell at 12 m

21

11.2% (3.6–18.3%)

23.2% (14.9–30.8%)

0.34 (0.17–0.69)

0.002