Fig. 3: Correlation between serum HMW and LMW uPA levels and HER2 tumor status in 100 breast and oesophageal cancer patients. | British Journal of Cancer

Fig. 3: Correlation between serum HMW and LMW uPA levels and HER2 tumor status in 100 breast and oesophageal cancer patients.

From: Differentiating borderline HER2-expressing and HER2-positive cancers from other subtypes using serum urokinase plasminogen activator

Fig. 3: Correlation between serum HMW and LMW uPA levels and HER2 tumor status in 100 breast and oesophageal cancer patients.The alternative text for this image may have been generated using AI.

a The semi-logarithmic dependences of e-ELASA responses on the total uPA (cyan) and HMW uPA (wine) concentrations in uPA-spiked 10% human (error bars are smaller than some concentration dots). b, c Correlation between the serum total uPA (blue) and HMW uPA (red) levels and the patients’ HER2 status based on analysis of serum samples from cancer patients with not overexpressed HER-2/neu (n = 52) and with allegedly HER2 positive types (n = 32). Healthy volunteers’ data (n = 30) are in Figs. S9 and SI. d–f Serum HMW uPA and (h–j) LMW uPA levels stratified by (d, h) patients’ cancer status, (e, i) HER-2/neu expression levels, and (f, J) ICH scores. g, k ROC curves obtained for (g) HMW uPA and (k) LMW uPA analysis of tumour’s HER2 status based on HER-2/neu expression (l, m) Serum LMW uPA levels stratified by HER-2/neu expression levels for (l) breast cancer and (m) oesophageal cancer; and (n, o) corresponding ROC curves for (n) breast cancer and (o) oesophageal cancer based on HER-2/neu expression. p Scheme of patients´ liquid biopsy analysis. The value of serum uPA analysis for borderline expression and overexpression of HER-2/neu: true positives (TP), true negatives (TN), false positives (FP) and false negatives (FN) of the allegedly HER2-positive group obtained by (q) detecting the total uPA and (r) detecting LMW uPA. The sensitivity calculated as TN/(TN + FP) and the selectivity calculated as TP/(TP + FN). The rest notations/conditions are as in Fig. 1 (samples preparation and statistics).

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