Fig. 2 | Cancer Gene Therapy

Fig. 2

From: Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging

Fig. 2

High-resolution tumor imaging with precise anatomical localization using NIS. a, b C57Bl/6 mice were implanted intravenously with LL/2-mNIS cells; a representative mouse is shown. LL/2-mNIS tumors were imaged by PET/CT using [18F]-TFB on day 27. Shown is a 3D rendering of tumor localization within the mouse (arrow indicates location of bone metastasis) a and 2D z-stack slices of the thoracic region (3-mm interval) b. c, d SCID beige mice were implanted intravenously with Nalm6-Fluc-hNIS cells; a representative mouse is shown. Nalm6-Fluc-hNIS tumors were imaged by BLI on day 26 c and by SPECT/CT using 125I on day 25 d

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