Fig. 2: Karyotype, FISH analysis, and Sanger sequencing of t(12;22)(p13;q12) and MN1-ETV6/ETV6-MN1.
From: Ectopia associated MN1 fusions and aberrant activation in myeloid neoplasms with t(12;22)(p13;q12)
FISH fluorescence in situ hybridization. a One karyotype of case P8, the arrows indicate t(12;22(p13;q13), trisomy 8, and del(20) (q11.2). b MN1 gene break-apart probe FISH test result of case P1. The separation of the red and green signals in one of the cells indicate a fracture of the MN1 gene or its vicinity. c, d Sanger sequencing of MN1-ETV6 (c) and ETV6-MN1 (d) transcripts.
