Fig. 5: Depletion of β-catenin affects the binding of FXR to SHP promoter induced by OCA. | Cancer Gene Therapy

Fig. 5: Depletion of β-catenin affects the binding of FXR to SHP promoter induced by OCA.

From: Synergistic tumor inhibition of colon cancer cells by nitazoxanide and obeticholic acid, a farnesoid X receptor ligand

Fig. 5

a, b The effect of depleting β-catenin expression on the binding of FXR protein to the SHP promoter in colon cancer cells detected by the qChIP assays. c The effect of ICG-001, an antagonist of β-catenin/TCF4 complex, on the binding of FXR protein to the SHP promoter in colon cancer cells detected the qChIP assays. d The effect of depleting β-catenin expression on the viability of colon cancer cells detected by CCK8 assays. All data are the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01.

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