Table 2 Predictive value of CHD1 deletion for BCR-free survival (multivariate cause-specific Cox proportional hazards model, n = 6831, events = 1705).

From: CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

 

HR

95% CI

P value

pT Stage*CHD1

  

0.011

pT2: CHD1 (del. vs norm.)

1.54

[1.23, 1.93]

<0.001

pT3a: CHD1 (del. vs norm.)

0.93

[0.71, 1.20]

0.564

pT3b/pT4: CHD1 (del. vs norm.)

1.12

[0.87, 1.44]

0.380

Age [per 10 years]

0.99

[0.91, 1.07]

0.741

Surgical margin (pos. vs neg.)

1.60

[1.44, 1.78]

<0.001

Gleason group

  

<0.001

3 + 4 vs ≤3 + 3

2.15

[1.80, 2.57]

<0.001

4 + 3 vs ≤3 + 3

4.26

[3.47, 5.24]

<0.001

≥4 + 4 vs ≤3 + 3

5.59

[4.34, 7.21]

<0.001

pN status

  

<0.001

Nx vs N0

0.76

[0.67, 0.87]

<0.001

N+vs N0

1.66

[1.41, 1.95]

<0.001

 PSA [per 10 units]

1.13

[1.09, 1.16]

<0.001

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