Fig. 5: Knocking out MIR21 promotes purine metabolism and decreases glutathione metabolism. | Cancer Gene Therapy

Fig. 5: Knocking out MIR21 promotes purine metabolism and decreases glutathione metabolism.

From: MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state

Fig. 5

A Principal component scores (PCA) of metabolites in whole lung tissues from wild-type (WT) and MIR21 knockout (KO) mice. N = 6 replicates. B Metabolic pathway analysis of lung tissues from MIR21 KO and WT mice. N = 6 replicates. C Top 40 metabolic hits differentially expressed in the lung tissues from MIR21 WT and KO mice. N = 6 replicates. D A diagram of purine metabolism. Red font indicates upregulated metabolites in comparing MIR21 KO and WT mouse lung tissues. E Upregulated metabolic hits in purine metabolism in lung tissues from the MIR21 KO mice compared with WT mice. N = 6 replicates. F Downregulated and upregulated metabolic hits in the glutathione metabolism pathway in lung tissues from MIR21 KO mice compared with WT mice. N = 6 replicates. G The ratio of glutathione disulfide (GSSG)/glutathione (GSH) in lung tissues from MIR21 KO mice compared with WT mice. N = 6 replicates. Data are mean ± s.e.m. and were analyzed with an unpaired two-tailed t-test (A, B, C, G).

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