Fig. 5: Fibroblasts expressing JAM-A cytoplasmic tail mutants show decreased sensitivity to reovirus-induced cell death.

A Overview of the different JAM-A constructs generated and expressed in hPS1 pancreatic stellate cells. B Cell surface expression of JAM-A on the hPS1 cells expressing vector control, full-length JAM-A and JAM-A cytoplasmic tail mutants. C Western blot for σ3 protein in the different JAM-A constructs infected with R124 and jin-3 for 48 h. D Cell viability of the hPS1 cells expressing the different JAM-A constructs after 72 h of infection with R124 or jin-3 at indicated MOIs. Two-way ANOVA for R124 and jin-3 MOI 10 conditions, *** = P ≤ 0.0001 E Crystal violet staining of the hPS1 cells expressing the different JAM-A constructs after 72 h of infection with R124 or jin-3 at indicated MOIs.