Fig. 6: The C-terminal PDZ-domain of JAM-A mediates reovirus-induced apoptosis in fibroblasts. | Cancer Gene Therapy

Fig. 6: The C-terminal PDZ-domain of JAM-A mediates reovirus-induced apoptosis in fibroblasts.

From: Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirus

Fig. 6

A Real-time microscopy (Tā€‰=ā€‰72ā€‰h) of Caspase3/7 cleavage in hPS1 pancreatic stellate cells expressing different JAM-A constructs after infection with R124 (top row) or jin-3 (bottom row).. Scale bar, 250ā€‰Ī¼m. B Quantification of Caspase3/7 signal in Relative Fluorescence Units for the entire duration of the experiment (72ā€‰h). Two-way ANOVA, ***ā€‰=ā€‰Pā€‰ā‰¤ā€‰0.0001ā€‰C Relative caspase 3/7 activation in hPS1 pancreatic stellate cells expressing different JAM-A constructs as compared to the vector control.

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