Fig. 5: KPNB1 decreases DDP sensitivity of melanoma cells. | Cancer Gene Therapy

Fig. 5: KPNB1 decreases DDP sensitivity of melanoma cells.

From: Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1

Fig. 5

A After the KPNB1-silenced or overexpressed cells were treated with DDP (0, 4, 8, 16, 32, or 64 μM), the IC50 value was calculated. B The apoptosis of KPNB1-silenced or -overexpressed cells treated with DDP. C Relative cleaved caspase 3 and cleaved PARP protein expression in KPNB1-silenced or overexpressed cells treated with DDP. N = 3. Data were shown as the mean ± SD. *P < 0.05 was determined by One-way ANOVA combined with Tukey’s post hoc test.

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