Fig. 1: A-485 inhibits cell growth in NSCLC cell lines. | Cancer Gene Therapy

Fig. 1: A-485 inhibits cell growth in NSCLC cell lines.

From: Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells

Fig. 1: A-485 inhibits cell growth in NSCLC cell lines.

Cell growth curves of A549 (A) and H1299 (B) cell lines, untreated or treated with A-485 at the indicated doses. About 5 × 104 cells were seeded on day 0 and treated on day 1. Clonogenic assay of A549 (C) and H1299 (D) cell lines, untreated or treated for 72 h with A-485 at the indicated doses. Representative images of colonies of A549 and H1299 cells stained with crystal violet are shown. The histograms represent the % of colony-forming cells relative to untreated ones. The results were statistically evaluated using Tukey’s multiple comparisons test, ***p < 0.0001. Cell growth curves of H460 (E) and H1650 (F) cell lines, untreated or treated with A-485 at the indicated dose. About 5 × 104 cells were seeded on day 0 and treated on day 1. A–F CTR represents 0.1% DMSO treated cells. The graphs represent the mean ± SD of three independent experiments.

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