Fig. 3: Identification of high affinity peptides to TLR4/MD-2 using alanine scanning based on the peptide #3 amino acid sequences. | Cancer Gene Therapy

Fig. 3: Identification of high affinity peptides to TLR4/MD-2 using alanine scanning based on the peptide #3 amino acid sequences.

From: Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway

Fig. 3

A Lists of peptides used for alanine scanning. Peptide3A5 displayed increased binding affinity to TLR4/MD-2 when compared to that of parental peptide#3. *P = 0.013. B Peptide3A5 is more potent for competitive inhibition on S100A8-TLR4/MD-2 complex than peptide #3. Similar results were obtained in three independent experiments. C The S100A8Lys77Ala recombinant protein decreased affinity to TLR4/MD-2. Data are shown as mean ± SD. *P < 0.05 compared with of full length of wild type (WT) S100A8.

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