Fig. 8: Model summarizing the multi-cancer LBH meta-analysis. | Cancer Gene Therapy

Fig. 8: Model summarizing the multi-cancer LBH meta-analysis.

From: Multi-cancer analysis reveals universal association of oncogenic LBH expression with DNA hypomethylation and WNT-Integrin signaling pathways

Fig. 8

In normal tissues, LBH regulates stem cells in embryonic development and tissue homeostasis. In gastrointestinal (COAD, READ, STAD, LIHC, PAAD), urological (KIRC, BLCA), and other cancers, the LBH gene locus is hypomethylated leading to increased LBH expression, in association with WNT/Integrin and inflammatory signaling pathways. In lung (LUAD) and skin (SKCM) cancer, LBH is downregulated, without DNA methylation changes, correlating with nucleotide synthesis, protein turnover, and neurodegeneration gene signatures, suggesting novel mechanisms of LBH regulation and function in carcinogenesis.

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