Fig. 3: IGF2BP3 is associated with a specific miRNA signature in EVs capable to clusterize EWS patients with high or low expression of IGF2BP3 at the tissue level. | Cancer Gene Therapy

Fig. 3: IGF2BP3 is associated with a specific miRNA signature in EVs capable to clusterize EWS patients with high or low expression of IGF2BP3 at the tissue level.

From: Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells

Fig. 3: IGF2BP3 is associated with a specific miRNA signature in EVs capable to clusterize EWS patients with high or low expression of IGF2BP3 at the tissue level.The alternative text for this image may have been generated using AI.

a Heatmap of differentially expressed miRNAs in IGF2BP3pos EVs versus IGF2BP3neg EVs extracted from A673 or TC-71 experimental models, respectively. b Heatmap unsupervised hierarchical clustering analysis of the commonly differentially expressed miRNA between IGF2BP3-EV-associated signature and those that were present in the dataset ArrayExpress accession: E-TABM-1100. The hierarchical clustering algorithm showed a distinct cluster of EWS patients with high expression of IGF2BP3 in the tumors compared to those with low expression. In the matrix, each row represents a miRNA, and each column represents a sample. The color scale illustrates the relative expression levels (z-score) of miRNAs across all samples: red represents the expression level above the mean and blue represents the expression lower than the mean.

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