Fig. 1: TGM2 is elevated in colon cancer tissue and is correlated with advanced tumor stages. | Cancer Gene Therapy

Fig. 1: TGM2 is elevated in colon cancer tissue and is correlated with advanced tumor stages.

From: Transglutaminase 2 is associated with adverse colorectal cancer survival and represents a therapeutic target

Fig. 1

A Representative photomicrographs (magnification = 100× and 200×) of immunohistochemical staining for TGM2 (brown) expression in tumor and normal tissue from CRC patients representing weak, moderate and strong expressing tumors. Expression levels were determined in epithelial cells by two independent investigators using a three-stage staining score. B TGM2 staining score in matched normal and tumor tissue of 7 CRC patients. C Mean TGM2 staining score according to T-stage, D N-stage, and E M-stage. Data are presented as mean immunoreactive score ± SD of IHC staining. Significance was determined using Wilcoxon matched pairs or Kruskal-Wallis test. F Prevalence of weak, moderate or strong TGM2 expression in 279 CRC patients according to their UICC stages. Correlation was calculated using Spearman correlation.

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