Fig. 2: Castration-induced dormant PCa PDXs showed decreased B7-H3 expression compared to active PDXs.
From: Influence of ADT on B7-H3 expression during CRPC progression from hormone-naïve prostate cancer
A B7-H3 IHC scores of 22 pairs of active and castration-induced dormant PDXs. The dormant status was further confirmed by serum PSA level and Ki67 count. A detailed list of PDXs and B7-H3, PSA, and Ki67 changes is shown in Supplementary Table S1. B Representative B7-H3 IHC images (×400 magnification) of normal prostate, as well as examples of active (Pre-Cx) and castration-induced dormant (12wk-Post-Cx) PCa PDXs. C Representative Western blot analysis of selected PDXs. T47D is a human breast cancer cell line used as a positive control. Castration: Cx.
